Prostate segmentation and surface reconstruction

This page contains instructions on how to perform MRI prostate segmentation and surface reconstruction in MIPAV. The algorithm facilities the validation of multi-parametric MRI with histopathology slides from radical prostatectomy specimens and targeted biopsy specimens. It employs the technique that combines image processing and computer aided design to construct a high resolution 3D prostate surface from MRI images in three orthogonal views with non-isotropic voxel resolution.

The algorithm includes 3 major steps:

1) Semi-automatic B-Spline registration-guided segmentation model, 2) Ball-pivoting and Poisson based 3D surface reconstruction, and 3) 3D printing for prostate mold.

The algorithm outline is shown below (TBD).

We present instructions on using the segmentation tool in step-wise order. An image dataset is also provided with the instruction, and the dataset can be obtained from: . For the image acquisition, the input data are MR images, which are obtained from a 3.0 T whole-body MRI system (Achieva, Philips Healthcare). T2-weighted MR images of the entire prostate were obtained in three orthogonal planes (sagittal, axial and coronal) at the scan resolution of 0.2734x0.2734x3.0 mm3; field of view 140 mm; image slice dimension 512x512. The center of the prostate is the focal point for the MRI scan. To reduce the scan time, a lower refocusing pulse of 100 degrees was used for sagittal and coronal images, which alters the contrast on these images compared to the axial images.